3 Hashimoto ’ s Thyroiditis
نویسندگان
چکیده
Hashimoto’s thyroiditis is a common autoimmune disorder, which causes significant morbidity. Its pathophysiological hallmark is lymphocytic infiltration of thyroid follicles resulting in autoimmune glandular destruction. Various studies have successfully outlined the genetic and environmental factors responsible for the causation of the disease. In this chapter we will discuss our current understanding of these factors and delineate how Hashimoto’s thyroiditis serves as a paradigm not just for disease of the thyroid gland, but also for autoimmune disease in the human body. Our focus is on the varying presentations of the disease and the relationship between Hashimoto’s thyroiditis and other autoimmune diseases frequently associated with it. The etiological factors and the pathophysiological changes which lead to the development of disease are discussed. Common diagnostic modalities are described, and the need for correlation between the various available diagnostic tests is explained. Various treatment strategies and the appropriate choice for different forms of presentation are discussed. Hashimoto’s encephalopathy, a rare complication, will be addressed separately as its unusual presentation often results in misdiagnosis of the underlying pathology.
منابع مشابه
A Case of Rathke\' s Cleft Cyst Associated with Diabetes Insipidus and Hashimoto\'s Thyroiditis
SUMMARY A 71 - year old woman with symptomatic Rathke's Cleft cyst is reported. She had Visual disturbance, diabetes insipidus and hypopituitarism. Imaging study with computed tomography revealed the presence of suprasellar mass. After the transsphenoidal surgery and treatment with DDA VP, her symptoms showed an improvement.
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